Statistical analysis is always an interesting field. For those gamblers either they perform structural or non-structural analysis on their own or using software.
E.g., in a 6/49 lottery (the most common world wide) there are 13,983,816 possible combinations. If, say, every combination were to come out just once, in random order, in 14 million draws, then at 2 draws per week (104 per year), it would take just under 135,000 years for ALL the combinations to come out.
To be assured of a 99.9% degree of certainty that your combination will hit, you would in fact have to play every draw for around 664,000 years!
I am not a gambler but part of my research includes statistical analysis.
Here is an interesting software for you to carry out statistical analysis on lotto, the MDIEditor and Lotto WE.